02062nas a2200277   4500008004100000245025200041210006900293260001400362300001200376490000700388520108500395653000901480653001501489653001401504653003501518653001001553100002401563700002401587700002801611700001901639700001901658700003001677700001701707700002401724856003601748       2020                        eng d00aCapsaicin Bioactive in Cabai (Capsicum Annum L.) as Anticancer Through Inhibition of over Ekspresi Protein Target RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK1) on Hepatocyt Cell Mice (mus musculus)0 aCapsaicin Bioactive in Cabai Capsicum Annum L as Anticancer Thro  cJune 2020  a911-9150 v123 a<p class="rtejustify">Capsaicin is a secondary metabolite of the Chilean plant. In the pharmaceutical field in addition to relieving pain or pain, capsaicin is also known to have anticancer activity because it inhibits certain oncogenic proteins. Screening of components in <em>Capsicum Annum</em> L. against the target proteins AKT1 and MAPK1 is needed as an initial stage of drug discovery. Further screening of Capsaicin compounds for oncogenic proteins produced in Hepatocellular carcinoma (HCC) pathogenesis signaling. In silico data that have been obtained, Capsaicin in chili (<em>Capsicum Annum</em> L.) has a high affinity for MAPK1 and AKT1 receptor/protein targets with energy and potential activity score (Pa) 0.690 for preneoplastic treatment, 0.590 for apoptotic agonists, and 0.366 for antineoplastic activity. Statistical data using Kruskal Wallis obtained information that Capsaicin can inhibit the expression of AKT 1 and MAPK 1 on mice hepatocyte cells induced by AFB1 <em>in vivo </em>administration, therefore it can be a candidate for anticancer drugs.</p>
10aAKT110aAnticancer10aCapsaicin10aHepatocellular carcinoma (HCC)10aMAPK11 aSukmanadi, Mohammad1 aSudjarwo, Sri, Agus1 aEffendi, Mustofa, Helmi1 aSrianto, Pudji1 a’am, Aulanni1 aMadyawati, Rr, Sri Pantja1 aLamid, Mirni1 aPlumeriastuti, Hani  uhttps://phcogj.com/article/1193