02567nas a2200205 4500008004100000245008300041210006900124260001600193300001400209490000700223520194600230653003002176653001902206653001802225653001702243653002502260100002102285700001902306856003602325 2020 eng d00aAnti-inflammatory Activity of Nigella sativa oil Mediated Silver Nanoparticles0 aAntiinflammatory Activity of Nigella sativa oil Mediated Silver  cAugust 2020 a1086-10920 v123 a

Aim: The aim of the study was to employ Nigella sativa oil in the synthesis of silver nanoparticles and to assess the anti-inflammatory activity of the Nigella sativa oil mediated silver nanoparticles. Background: The introduction of Nanoparticles (NPs) has transFigured many fields like medicine, nutrition and electronics. The usage of nanotechnology in medicine particularly for drug delivery is revealed to have numerous benefits. Nanoparticles are being used to decrease toxicity and side effects that drugs may impose to the patient. Nigella sativa is considered as a miracle seed. It has been reported to have anti-inflammatory, diuretic, and antihypertensive activity. Plant mediated biological synthesis of nanoparticles is simple and eco-friendly method. This work therefore was aimed to synthesize Nigella sativa oil mediated silver nanoparticles and evaluate its anti-inflammatory activity. Materials and Methods: Nigella sativa oil mediated silver nanoparticles were synthesised by short term (1 day) interaction of Nigella sativa seed extract (1 ml) with 2mM AgNO3 solution and centrifuged to obtain silver nanoparticles. The nanoparticles were characterised by UV-Visible spectrophotometer, FTIR and Scanning Electron Microscopy (SEM). Further the oil mediated AgNPs were evaluated for anti-inflammatory activity by in vitro and in vivo methods. Results: Nigella sativa oil mediated AgNPs were biofabricated with ease and exhibited good anti-inflammatory activity compared to standard. Conclusion: This study concludes that Nigella sativa seed oil mediated silver nanoparticles have the potential to be used as an effective antioxidant. Hence, it may be used in many medicinal applications to treat inflammation.

10aAnti- Inflammatory effect10aNigella sativa10aRananculaceae10aSEM analysis10aSilver nanoparticles1 aShehensha, Sheik1 aJyothi, Vijaya uhttps://phcogj.com/article/1205