02651nas a2200253 4500008004100000245011600041210006900157260001600226300001200242490000700254520188000261653001602141653001602157653001702173653001502190653002202205100002702227700002902254700001802283700001902301700001802320700002302338856003602361 2020 eng d00aNoni Juice (Morinda citrifolia) to Prevent Cancer Progression in Mice Induced DMBA and Cigarette Smoke Exposure0 aNoni Juice Morinda citrifolia to Prevent Cancer Progression in M cAugust 2020 a946-9510 v123 a

Introduction: Accumulation of polycyclic aromatic hydrocarbons (PAH) in the body commonly lead to degenerative disease such as cancer. This study aims to investigate the potential of Morinda citrifolia to maintain the immune system against toxic exposure. Materials and Methods: This study used Five weeks old male Balb/C mice as animal model. The 7,12-Dimethylbenz(a)anthracene (DMBA) was administrated for six weeks following with 3 days cigarette smoke (CS) exposure then treated with noni juice (M. citrifolia) for two weeks. Experimental animals were divided into six groups. Normal control (N); DMBA+CS; Cisplatin; D1; D2; and D3. Profil of CD4+TNFα+, CD11b+IL6+, CD11b+IFNγ+, CD4+CD25+ IL10+, NK+IL6+ cells was analyzed by flow cytometry and data was analyzed with one-way ANOVA and Post Hoc Tukey HSD test with a significance of p-values < 0.05. Results: This study show that DMBA+CS induction increasing level of CD11b+IL6+, CD4+CD25+ IL-10+ and NK+ IL-6+ meanwhile decreasing CD4+TNFα+significantly (P<0.5) than Normal group. Noni juice in dose 90 mg/Kg BW decrease cytokine pro-inflammation (IL-6 and IFNγ) both in macrophage and NK cell profile significantly (P<0.05). Noni juice in 30 mg/Kg BW could improve the activation CD4+TNFα+ significantly (P<0.05). Noni juice also has efficacy to control T regulator activation to prevent tumor escape. Conclusion: These results suggest that noni juice has anti-cancer potencies by maintain homeostasis of immune system and could be immune herbal supplement.

10aHomeostatic10aImmunotoxin10aInflammation10aNoni juice10aTumor progression1 aAgustina, Didin, Wahyu1 aWahyuningsih, Mulya, Dwi1 aWidyarti, Sri1 aSoewondo, Aris1 aTsuboi, Hideo1 aRifa’i, Muhaimin uhttps://phcogj.com/article/1206