01683nas a2200217 4500008004100000245011200041210006900153260001600222300001400238490000700252520101700259653001301276653002801289653001001317653001201327100001601339700002601355700002101381700002701402856003601429 2020 eng d00aPotential Test of Nephropathy Sonchus arvensis L. Leaves on Male Rats (Rattus norvegicus) Diabetes Mellitus0 aPotential Test of Nephropathy Sonchus arvensis L Leaves on Male  cAugust 2020 a1115-11200 v123 a

This study aims to determine the type of secondary metabolites compounds of the ethanol Sonchus arvensis L leaves extract, the effect of ethanol Sonchus arvensis L leaves extracts the levels of blood glucose and a histopathology picture male white rat induced by streptozotocin. This study used 30 males white rats which were divided into 6 groups, namely the control of normal, negative control, positive control, doses of 200, 300 and 400 mg/kg BW. Results of the study showed that the ethanol Sonchus arvensis L. leaves extracts contained compounds of alkaloids, flavonoids, phenols, saponins and tannins. Sonchus arvensis L ethanol extract at a dose of 300 mg/kg BW is an effective dose in reducing blood glucose levels with an average value of decreasing blood glucose levels 101.6 mg / dL and has an effect on the regeneration of renal tubular cells with an effective dose is 300 mg / kg body weight with an average damage value of 0.28.

10aDiabetes10aLeaf Sonchus arvensis L10aRenal10aTubular1 aTandi, Joni1 aSutrisna, Nyoman, Edi1 aPratiwi, Mentari1 aHandayani, Tien, Wahyu uhttps://phcogj.com/article/1218