02435nas a2200313 4500008004100000245011400041210006900155260001900224300001400243490000700257520139400264653001401658653000901672653002201681653001801703653001801721100002401739700002801763700003001791700003401821700003201855700002901887700003301916700002901949700003301978700004202011700003202053856003602085 2020 eng d00aWound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c0 aWound Healing Activity of an Ointment from Solanum tuberosum L T cSeptember 2020 a1268-12750 v123 a

Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato" were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation.

10aHistology10aSkin10aSolanum tuberosum10aWound Healing10aYellow potato1 aRosas-Cruz, Galy, P1 aSilva-Correa, Carmen, R1 aCalderón-Peña, Abhel, A1 aLa Torre, Víctor, E Villarre1 aAspajo-Villalaz, Cinthya, L1 aCruzado-Razco, José, L.1 aDel Rosario-Chávarri, Jorge1 aRodríguez-Soto, Juan, C1 aPretel-Sevillano, Orlando, E1 aSagástegui-Guarniz, William, Antonio1 aGonzález-Siccha, Anabel, D uhttps://phcogj.com/article/1242