02026nas a2200229 4500008004100000245017100041210006900212260001900281300001400300490000700314520127500321653002501596653000901621653001301630653002301643100001701666700001501683700002101698700002301719700001801742856003601760 2020 eng d00aComparison of Cytotoxicity between Ethyl Acetate and Ethanol Extract of White Turmeric (Kaempferia rotunda) Rhizome Extract Against HeLa Cervical Cancer Cell Activity0 aComparison of Cytotoxicity between Ethyl Acetate and Ethanol Ext cSeptember 2020 a1297-13020 v123 a

Aim: The aim of this study is to compare between ethanol and ethyl acetate rhizome extract of K.rotunda against HeLa cervical cancer cell in vitro. Material and Methods: Methods used in this research are test the chemical compound of extracts using Thin Layer Chromatography (TLC) and phytochemical screening test, also cytotoxicity test using MTT assay. Result: Ethyl acetate extract contains flavonoid, alkaloid, tannin, and triterpenoid, while ethanol extract have flavonoid, triterpenoid, and alkaloid. In addition, ethanol extract has strong cytotoxic activity (IC50 = 16,939 μg/ml) while ethyl acetate extract has moderate cytotoxic activity (IC50 = 127,9 μg/ml). Each of extracts showed significant results (p ≤ 0,05) although when compared between concentrations there are several concentrations that are not significant and also small coefficient of determinant values caused by various confounding factors. Conclusion: The ethanol extract of K.rotunda rhizome extract has the higher cytotoxicity activity compared to ethyl acetate extract of K.rotunda rhizome extract against HeLa cervical cancer cell.

10aAnti cervical cancer10aHeLa10ain vitro10aKaempferia rotunda1 aDwira, Surya1 aTP, Ariska1 aFadilah, Fadilah1 aAzizah, Norma, Nur1 aErlina, Linda uhttps://phcogj.com/article/1245