02276nas a2200277 4500008004100000245012800041210006900169260001900238300001400257490000700271520138500278653001401663653001801677653002201695653000801717653002001725100002401745700002801769700003101797700002801828700002101856700003001877700002401907700003101931856003601962 2020 eng d00aBlack Horehound (Ballota nigra Linn) Induces Apoptosis in Prostate Cancer Cells (PC-3) Through Intrinsic Signalling Cascade0 aBlack Horehound Ballota nigra Linn Induces Apoptosis in Prostate cSeptember 2020 a1377-13820 v123 a

Background: Prostate cancer is the most commonly diagnosed cancer among men. The disease varies widely in its clinical aggressiveness. Ballota nigra Linn (Black horehound) is a three-foot, perennial herb of the family Lamiaceae and it has been shown to have various pharmacological properties such as antioxidant, hypoglycemic, neuro-sedative, antibacterial, insecticidal and anticholinesterase activities. However, the elucidation of B.nigra for its anticancer activity in prostate cancer has not been studied so far. Methodology: Prostate cancer PC3 cells were treated with different concentrations of B.nigra (50, 100, 200 & 400μg/ml) for the analysis of Bcl-2, Phosphorylation of Bcl2 (p-Bcl2) and tumor suppressor protein p53, Case pase-3 and caspase-9 in PC3 cells. Results: The B.nigra ethanolic leaf extract reduced the levels of anti apoptotic proteins (Bcl-2, p-Bcl2) and increased the level of tumor suppressor protein p53, caspase-3 and 9 significantly (p<0.05). Conclusion: Results of the study show that B.nigra has potential anticancer activity by modulating intrinsic activity of apoptotic signaling in PC-3 cells. Thus, B.nigra may have a potential therapeutic option for the treatment of prostate cancer.

10aApoptosis10aBallota nigra10aIntrinsic pathway10aPC310aProstate cancer1 aJayaraman, Selvaraj1 aRajagopal, Ponnulakshmi1 aVeeraraghavan, Vishnupriya1 aSivagnanam, Poonguzhali1 aRavikumar, Divya1 aSuga, Sumetha, Suga Deiva1 aJames, Kavin, Mozhi1 aMohan, Surapaneni, Krishna uhttps://phcogj.com/article/1256