02159nas a2200205 4500008004100000245010000041210006900141260001900210300001400229490000700243520152200250653000801772653003401780653002101814653002101835653001901856100002301875700001901898856003601917 2020 eng d00aSoutheast Asian Medicinal Plants with Angiotensin Converting Enzyme (ACE) Inhibition Properties0 aSoutheast Asian Medicinal Plants with Angiotensin Converting Enz cSeptember 2020 a1429-14390 v123 a

Introduction: This article aims to provide a summary of medicinal plants in the Southeast Asian countries that have an angiotensin-converting enzyme (ACE) inhibitory activity that is therapeutically useful for treating hypertension. Methods: This review paper is a result of extensive searches via electronic database platforms, including Pubmed, Google Scholar, Scopus, and Science Direct with the keyword search terms: ACE enzyme, Southeast Asia countries, plants, and extracts. Results: Thirty-four articles on ACE inhibition activity of 76 Southeast Asian medicinal plants were found and further reviewed. Several plants from Malaysia (Chassalia curviflora, Citrus hystrix, Murraya koenigii, Senna garrettiana), Indonesia (Gnetum Gnemon, Momordica charantia, Nasturtium officinale, Peperomia pellucida, Pereskia saccharose), and Thailand (Mammea siamensis) were found to exhibit strong ACE inhibitory activity in vitro. Bioactive compounds such as 3’,4’, dihydroxy-3-5 dimethoxy flavone-7-O- β-rhamnose and quercetin-3-O-glucoside showed the highest potency in exhibiting the ACE inhibition activity in this review. Conclusions: This review suggests for an in-depth investigation on the potent crude extracts for the potential development of complementary herbal medicines as well as on the potent ACE inhibitor compounds for further development as new ACE inhibitor candidates for hypertension therapy.

10aACE10aAngiotensin-converting enzyme10aAntihypertensive10aMedicinal plants10aSoutheast Asia1 aAnuar, T, A Faiz T1 aIsmail, Azlini uhttps://phcogj.com/article/1263