02425nas a2200253 4500008004100000245011200041210006900153260001800222300001400240490000700254520163600261653002001897653001101917653002401928653002101952100001801973700001801991700002102009700002802030700003002058700002002088700002702108856003602135 2020 eng d00aEffect of Afghan Saffron (Crocus sativus L.) Aqueous Extract on Withdrawal Signs in Morphine-Dependent Rats0 aEffect of Afghan Saffron Crocus sativus L Aqueous Extract on Wit cNovember 2020 a1727-17310 v123 a

Introduction: Opioid dependency, as a global problem is accompanied with serious personal, economic, social and hygienic disorders. Synthetic drugs beside their efficacies, have numerous adverse effects. As the medicinal plants have low costs and adverse effects, and they are also affective on different stages of dependency treatment, they attracted the attention of the researchers in the field of medicine. This study was aimed to investigate the effect of the aqueous extract of Afghan saffron on the withdrawal signs in morphine-dependent rats. Methods: Rats divided into 5 groups (1 Normal Saline, 1 Morphine, and 3 Extract groups). The rats that received morphine and extract became morphine-dependent by subcutaneous (s.c.) administration of morphine hydrochloride for 7 days (2.5, 2.5, 5, 10, 20, 40 mg/kg doses twice daily on 1st to 6th days respectively, and a single dose of 50 mg/kg on 7th day). The extract groups received 100, 150 and 200 mg/kg doses of the saffron aqueous extract by intraperitoneal (i.p.) administration simultaneously with morphine. Two hours after the administration of the last dose of morphine, Naloxone (3 mg/kg, i.p.) was injected and withdrawal signs were noted for 30 minutes. Results: The results showed that the administration of the saffron aqueous extract (100, 150 and 200 mg/kg) significantly decreased most of the withdrawal signs in morphine-dependent rats (P<0.05). Conclusion: Afghan saffron aqueous extract can alleviate the withdrawal signs in morphine-dependent rats.

10aAqueous extract10aCrocus10aMorphine dependence10aWithdrawal signs1 aAkbari, Elham1 aAlami, Kawsar1 aHossaini, Dawood1 aNazari, Mohammad, Latif1 aSalehi, Mohammad, Hossein1 aSajjadi, Meysam1 aMousavi, Sayed, Yousof uhttps://phcogj.com/article/1287