02664nas a2200217 4500008004100000245014400041210006900185260001800254300001400272490000700286520195800293653001402251653002702265653002502292653002502317100002002342700001602362700001702378700001502395856003602410 2020 eng d00aHepatoprotective Effect of Bioactive Fraction of Lagerstroemia speciosa (L.) Pers. Bark Against Monosodium Glutamate-Induced Liver Toxicity0 aHepatoprotective Effect of Bioactive Fraction of Lagerstroemia s cNovember 2020 a1630-16400 v123 a

Background: The phenolics and flavanoid enriched bioactive fraction of L. speciosa bark were reported for its medicinal value in various illness however hepatoprotective activity against monosodium glutamate-induced liver toxicity yet to be reported. Objective: To evaluate the hepatoprotective and antioxidant potential of L. speciosa bark extract fraction against monosodium glutamate-induced liver toxicity. Methods: The phytochemical constituent of ethyl acetate fraction of L. speciosa bark extract (LSE) were identified by GC-MS analysis. The antioxidant activity of LSE were analyzed with in-vitro antioxidant assay and subjected to evaluate hepatoprotective activity against monosodium glutamate induced liver toxicity in rat. Results: LSE evaluated as rich in phenolics and flavonoid content along with potent hepatoprotective activity. GC-MS analysis of bioactive fraction exhibits Palmitic Acid, Octadecanoic acid, 5-methyluridine, catechine, epigallocatechin, and norgestrel as major biologically active phytocompounds. Oral administration of LSE (100 and 200 mg/kg.) declined the elevated levels of the biochemical marker as well as interleukins while enhanced the enzymatic antioxidant activity and reduced the increased level of stress marker (MDA) in monosodium glutamate-induced rats. It also restored the altered expression level of proapoptotic genes, but there is no significant change in the expression level of the anti-apoptotic gene. LSE improved histopathology of the liver through the improvement of hepatocellular architecture, inflammation, and attenuation of vascular and cellular degeneration. Conclusion: The bioactive fraction of L. speciosa bark was found to exhibit strong antioxidant and hepatoprotection in monosodium glutamate induced liver toxicity in rats.

10aApoptosis10aLagerstroemia speciosa10aMonosodium glutamate10aSuperoxide dismutase1 aPal, Lal, Chand1 akumar, Anil1 aPande, Veena1 aRao, Ch, V uhttps://phcogj.com/article/1314