02296nas a2200217 4500008004100000245012600041210006900167260001800236300001200254490000600266520162400272653001201896653001901908653002001927653001601947100001601963700002401979700001902003700002102022856003502043 2016 eng d00aHepatoprotective effect of Prunus armeniaca L. (Apricot) leaf extracts on Paracetamol induced liver damage in Wistar rats0 aHepatoprotective effect of Prunus armeniaca L Apricot leaf extra cDecember 2015 a154-1580 v83 a

Objective: To evaluate the hepatoprotective effect of Prunus armeniaca L. (Apricot) leaf on paracetamol induced liver toxicity in rats. Method: Phytochemical investigation was performed to find active constituents of the plant extracts by the different phytochemical tests. After induction of liver toxicity, the biochemical parameters such as serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT), serum alkaline phosphatase (sALP), serum bilirubin (SB), thiobarbituric acid reactive substances (TBARS), γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total protein (TP), albumin. The physical parameters including liver weight, body weight and histopathological changes in the liver were studied with Ursodeoxycholic acid as standard hepatoprotective agents. Results: The phytochemical investigation of the extracts showed the presence of Alkaloids, volatile oil, saponin glycosides, condensed tanins, terpenoids, steroids and flavonoids. Methanol and aqueous extract before the paracetamol administration caused a significant reduction in the values of sGOT, sGPT, sALP, TBARS, GGT, LDH TP, Albumin and sB (P<0.01) almost comparable to the Ursodeoxycholic acid. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusions: The result concludes that Prunus armeniaca L. possesses the hepatoprotective effect against paracetamol induced liver toxicity in rats.

10aApricot10aHepatotoxicity10aLiver toxicity.10aParacetamol1 aRaj, Varsha1 aMishra, Arun, Kumar1 aMishra, Amrita1 aKhan, Najam, Ali uhttps://phcogj.com/article/132