02196nas a2200217 4500008004100000245011100041210006900152260001800221300001400239490000700253520156600260653002201826653000801848653002301856653001001879653000801889653000801897100001201905700002501917856003601942 2020 eng d00aSeagrass in the Control of Hyperglycemic and Hyperlipidemic States of Streptozotocin Induced Diabetic Rats0 aSeagrass in the Control of Hyperglycemic and Hyperlipidemic Stat cNovember 2020 a1716-17210 v123 a

Background: The present study intended to evaluate the beneficial effects of the seagrass Halophila beccarii, against induced diabetes mellitus in rat models. Halophila beccarii is a type of Seagrass abundant in Pulicat Lake of Andhra Pradesh, India. Objective: Evaluating the anti-hyperglycemic and anti-hyperlipidemic properties of seagrass extract in comparison with standards. Materials and Methods: STZ induced diabetic rat models were adopted to analyze the effect of long-term treatment with seagrass extract on blood glucose, HbA1c and serum lipids. Results: The methanolic extract of seagrass demonstrated a significant drop of blood glucose levels (52%), in diabetic rats, after 6 h of supplementation. After 40 days of treatment with 500 mg/day of seagrass extract, STZ diabetic rats exhibited tremendous decrease in fasting blood glucose with significant improvement in glycemic control as evidenced by controlled levels of HbA1c. Lower levels of triglycerides, total cholesterol, LDL and VLDL cholesterols and higher levels of HDL cholesterol in STZ-induced diabetic rats provided an evidence for significant anti hyperlipidemic property of seagrass extract. Conclusion: Phytochemicals of seagrass like phenols, flavonoids and bioactive lipids contribute to the anti-hyperglycemic and anti-hyperlipidemic activities and Halophila beccarii extract serves as a natural supplement in the management of diabetes.

10aDiabetes mellitus10aFBG10aHalophila beccarii10aHbA1c10aHDL10aLDL1 aVani, M1 aDevi, Uma, Maheswari uhttps://phcogj.com/article/1321