01960nas a2200217   4500008004100000245012900041210006900170260001300239300001200252490000700264520121800271653002401489653002101513653002301534653002801557653002701585100003101612700002701643700003601670856003601706       2021                        eng d00aNephro- and hepatoprotective effect of Rosmarinus officinalis against damage induced with antiTB drugs using a chronic model0 aNephro and hepatoprotective effect of Rosmarinus officinalis aga  cMay 2021  a722-7290 v133 a<p>Nephro- and hepatoprotector effect of MeOH extract from <em>R. officinalis</em> against the liver and kidney damage caused by the mixture of RIF:INH:PZA, using a chronic<em> in vivo</em> model are described. MeOH extract (EMRO) was prepared by maceration process and was administered by oral via during 91 days in male Balb/C mice with RIF:INH:PZA-induced renal/liver damage, using silymarin (SIL) as a positive control. EMRO (250 mg/kg) favoured body weight gain respect to the antiTB group, this gain was better than that shown by the SIL. The AST and ALT values of the group that received the EMRO extract and SIL were similar to that the control group and low compared to the group antiTB with liver damage. In addition, the GPx, CAT and POx values of the group treated with the EMRO were similar to that the control group. In the liver histological analysis, no significant alteration was observed; however, a severe nephritis was observed in anti-TB group (II) and this effect was less in groups III (antiTB/SIL) and IV (antiTB/EMRO). MeOH extract enhances body weight gain and primarily protects the kidney and liver from damage caused by the antiTB drug mixture when was administered for 91 days.</p>
10aAntitubercular drug10aHepatoprotection10aMethanolic extract10aNephroprotective effect10aRosmarinus officinalis1 aA, Siordia-Reyes, Georgina1 aJorge, Cornejo-Garrido1 aAdelina, Jiménez-Arellanes, M.  uhttps://phcogj.com/article/1418