02122nas a2200229 4500008004100000245008700041210006900128260001300197300001200210490000700222520135800229653001701587653002401604653003801628653003601666100002801702700003701730700002101767700003001788700003801818856003601856 2021 eng d00aAntihypertensive Effects of Osteospermum Imbricatum in Two Hypertensive Rat Models0 aAntihypertensive Effects of Osteospermum Imbricatum in Two Hyper cMay 2021 a744-7510 v133 a

Introduction: Osteospermum imbricatum is used traditionally in Eastern Cape, South Africa for the management of hypertension, chest and stomach complaints. This study was aimed at investigating the antioxidant and antihypertensive effects of this plant. Methods: Antioxidant capacity was determined by radical scavenging assays and ferric reducing antioxidant power. Antihypertensive effects after once off treatment with the leaf/root extracts (500 mg/kg) were evaluated in spontaneously hypertensive rats (SHR). The effect of the extracts on established hypertension was determined in Wistar rats treated with Nω-Nitro-L-arginine methyl ester (L-NAME) (40 mg/kg/day) for 4 weeks followed by co-treatment with L-NAME and extracts (200 mg/kg and 400 mg/kg) or amlodipine (5 mg/kg) or normal saline for 4 more weeks. Results: The concentration at which there was 50 % inhibition (IC50) of DPPH radical by the extracts was lower for the leaf extract (0.79 mg/mL) compared to the root extract (1.15 mg/mL). The leaf extract significantly (p<0.01) decreased systolic and diastolic blood pressures in both rat models. Conclusion: The extracts of Omsteospermum imbricatu have moderate antioxidants and antihypertensive properties.

10aAntioxidants10aHigh blood pressure10aNω-Nitro-L-arginine methyl ester10aSpontaneously hypertensive rats1 aTata, Charlotte, Mungho1 aSewani-Rusike, Constance, Rufaro1 aAremu, Olukayode1 aOyedeji, Opeoluwa, Oyehan1 aNkeh-Chungag, Benedicta, Ngwenchi uhttps://phcogj.com/article/1421