02659nas a2200265 4500008004100000245015500041210006900196260001800265300001200283490000600295520179700301653002202098653001602120653001702136653001902153653002202172100002402194700001602218700002002234700002902254700000502283700003702288700003202325856003602357 2015 eng d00aPhytochemical analysis and in vitro antioxidant, antimicrobial, anti-inflammatory and cytotoxicity activities of wood rotting fungi, Trametes ochracea0 aPhytochemical analysis and in vitro antioxidant antimicrobial an c8th Jan, 2015 a136-1460 v73 a

Objective: The present research was aimed to identify the metabolites in the methaolic and hexane extract of Trametes ochracea and evaluated these extracts to know their in vitro biological activities. Materials and methods Two solvent extracts of T. ochracea was subjected to phytochemical analysis. The two solvent extracts were subjected to in vitro biological activity viz., antioxidant, anti-inflammatory and cytoxicity assays. Results: The methanol extract yielded important phytochemicals viz., saponins, flavonoids, alkaloids, steroids, phenols and tannins compared to hexane. The methanolic extract has shown strong antioxidant activity in all tested methods: The methanol extract was effectively inhibited the heat induced hemolysis, antilipoxygenase activity and also stabilized the membrane, avoided the membrane denaturation, proteinase and xanthine oxidase inhibition.The onion root meristametic cells were inhibited due to toxicity of methanol extract by possessing various cellular abnormalities in various stages of actively growing cells. The yeast cells were dead due to toxicity of methanol extract by possessing cell necrosis and also fragmented the cell DNA. Conclusions: The obtained results clearly indicates that Trametes ochracea methanol extract is having potent phytochemicals, which plays important role in antioxidant, anti-inflammatory, cytotoxicity assays. The further research is needed to identify the exact mechanism is by action of one or combination of active phytochemicals.

Key words: Trametes ochracea, Phytochemicals, Antioxidant, Anti-inflammatory, Cytotoxicity.

10aAnti-inflammatory10aAntioxidant10aCytotoxicity10aPhytochemicals10aTrametes ochracea1 aMelappa, Govindappa1 aRoshan, Ara1 aNithi, Chanduri1 aMohummed, Thouseef, Syed1 a1 aRamachandra, Yerappa, Lakshmikan1 aPoojari, Chandrappa, Chinna uhttps://phcogj.com/article/1446