02007nas a2200217 4500008004100000245010400041210006900145260001900214300001200233490000600245520133200251653001601583653002101599653002401620653001601644653001501660100002001675700002901695700002901724856003601753 2015 eng d00aHepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats0 aHepatoprotective Activity of Michelia nilagirica against Paracet c29th Apr, 2015 a228-2350 v73 a

Background:Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. Materials & Methods: Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. Results: The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) & Serum bilirubin. Conclusion: Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.

Key words: Albino rats, Hepatoprotective, Michelia nilagirica, Paracetamol, Screening.

10aAlbino rats10aHepatoprotective10aMichelia nilagirica10aParacetamol10aScreening.1 aAminabee, Shaik1 aRao, Atmakuri, Lakshmana1 aEswaraiah, Maram, Chinna uhttps://phcogj.com/article/1453