02795nas a2200277 4500008004100000245013700041210006900178260001900247300001200266490000600278520188900284653002802173653002302201653002202224653002202246653001602268100002802284700003202312700002202344700002302366700002802389700002602417700001902443700001902462856003602481 2015 eng d00aEffectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism0 aEffectiveness of Sidr Honey on the prevention of ethanolinduced  c13th Feb, 2015 a157-1640 v73 a

Background: Sider (Ziziphus spina-christi (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. Aim of the study: The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. Materials and methods: Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95%ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. Results: Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax). Conclusion: Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.

Key words: Antiapoptotic Mechanism, Antioxidant Agents, Gastro protection, Monofloral Nectar, Sidr Honey.

10aAntiapoptotic Mechanism10aantioxidant agents10aGastro protection10amonofloral nectar10aSidr Honey.1 aTaha, Manal, Mohamed El1 aAbdelwahab, Siddig, Ibrahim1 aElsanousi, Rashad1 aSheikh, Bassem, Y.1 aAbdulla, Mahmood, Ameen1 aBabiker, Saif, Eldeen1 aElraih, Husham1 aMohamed, Eldaw uhttps://phcogj.com/article/1475