02183nas a2200193 4500008004100000245014500041210006900186260001900255300001000274490000600284520157800290653002001868653001801888653002301906100000501929700000501934700001401939856003601953 2014 eng d00aAssessment of anti hyperglycemic fractions isolated from Albizia procera stem bark chloroform extract using STZ induced diabetic albino rats0 aAssessment of anti hyperglycemic fractions isolated from Albizia c8th April 2014 a29-350 v63 a

Objective: The present Study was to identify more effective hypoglycemic fractions from chloroform extract of Albizia procera stem bark. Material and methods: Isolated fractions of Albizia procera stem bark chloroform extract were given individually to different batches of rats both normal (80 mg/kg of b.wt animals) and STZ induced diabetic rats (160mg/kg b.wt animals) after an overnight fast. The blood glucose levels were measured at 0, 1, 2, 3, 5 and 6 hours after the treatment. Fractions were also treated to STZ induced diabetic rats by chronically (80mg/kg b.wt). Results: The fractions E of Albizia procera stem bark chloroform extract was shown maximum blood glucose lowering effect in both normal and STZ diabetic rats with acute and chronic treatment. The other fractions are also showing hypoglycemic and antihyperglycemic activity, but the effect is significantly less than that of fraction E. The antihyperglycemic activity of fractions of Albizia procera stem bark chloroform extract was compared with the treatment of glibenclamide. Conclusion: The present data confirm the anti diabetic activity of Albizia procera in Indian traditional medicine for Diabetes mellitus treatment. The anti hyperglycemic action attributed to the presence of valuable flavonoids, terpinoids in the fraction E.

Key words: Albizia procera, hyperglycemia, Streptozocin (STZ).

10aAlbizia procera10ahyperglycemia10aStreptozocin (STZ)1 a1 a1 aK, Prasad uhttps://phcogj.com/article/1486