02541nas a2200205 4500008004100000245011600041210006900157260001800226300001000244490000600254520192100260653001802181653003102199653001902230653002102249100000502270700000502275700001902280856003602299 2014 eng d00aAlpha glucosidase inhibitory activity of hydro-methanolic (2:3) extract of seed of Swietenia mahagoni (L.) Jacq0 aAlpha glucosidase inhibitory activity of hydromethanolic 23 extr c18th Feb,2014 a63-690 v63 a

Objectives: Present study investigated the effect of hydro-methanolic extract of seed of Swietenia mahagoni (HMESM) on a-glucosidase inhibition in normal and streptozotocin-induced diabetic rats. Methods: Oral carbohydrate tolerance tests were performed in 16h fasted normal and diabetic rats loaded with starch or sucrose or glucose at the dose of 3g/kg, 15min after administration of 250 (S1), 500 (S2), 1000 (S3) mg/kg of HMESM, vehicle (control),or pretreatment at the dose of 10 mg/kg of acarbose (Acar). Blood samples were analyzed for glucose levels at 0, 30th, 60th, and 120th min after respective treatments and the peak blood glucose (PBG) levels and area under the curves (AUC) were determined. Results: Results demonstrated that 500 mg, 1000 mg/kg of HMESM reduced and prolonged the PBG and decreased AUC simultaneously after starch and sucrose loading in normal and diabetic rats. Similarly acarbose also reduce the sucrose and starch induced blood glucose excursion, whereas it had no peak blood glucose suppressive effect after exogenous glucose load in both normal and diabetic rats. On the other hand, phytochemical study of the said extract revealed that it is rich in phenolic compounds (46.25 mg of gallic acid equivalent/g of extract) and flavonoids (231.72 mg of quercetin equivalent/g of the extract), which may may responsible for pharmacological activities. Conclusion: The HMESM may have PBG suppressive effect in post-carbohydrate challenged state as evidenced by reduced PBG and AUC. This suggest that HMESM may be used effectively as a safer alternative to control postprandial hyperglycemia especially in pre-diabetic and diabetic patients.

Key words: Streptozotocin,∝-glucosidase, Postprandial hyperglycemia, Total flavono.

10aa-glucosidase10aPostprandial hyperglycemia10aStreptozotocin10aTotal flavonoids1 a1 a1 aGhosh, Debidas uhttps://phcogj.com/article/1535