02166nas a2200193 4500008004100000245014200041210006900183260001400252300001200266490000700278520151200285653001701797653002301814653001901837100002401856700002901880700002701909856003601936 2021 eng d00aRepairing of Renal Tubules in Diabetic Rats (Rattus norvegicus) Diabetes After Administration of Golden Sea Cucumber (Stichopus hermanii)0 aRepairing of Renal Tubules in Diabetic Rats Rattus norvegicus Di cJuly 2021 a958-9640 v133 a

This study aims to analyze the improvement of the histopathological picture of renal tubules in diabetic rats after being given golden sea cucumber extract (Stichopus hermanii). This research uses experimental design laboratories with a post-test only control group design method. The sampling used simple random sampling with 25 white rats divided into five groups, namely groups that were given standard feed without STZ-induced, STZ-induced group, STZ-induced group and given golden sea cucumber extract at a dose of 4.25 mg/kg BW for 21 days, STZinduced group and given golden sea cucumber extract at a dose of 8.5 mg/kg BW for 21 days, and STZ-induced group and given gold sea cucumber extract at a dose of 12.75 mg/kg BW for 21 days. The data on the observation of each group's kidney histopathology was carried out at the end of the session. The results of the analysis using the Kruskal-Wallis Test showed significant results, the Mann-Whitney Test showed significant differences between the STZinduced group and the golden sea cucumber extract (Stichopus hermanii) dose of 12.75 mg/kg BW (x=7.4 mg/dl) decreased significantly (p=0.001) compared to the STZ-only-induced group (x=12.6 mg/dl). Administration of golden sea cucumber extract (Stichopus hermanii) at a dose of 12.75 mg/kg BW of rats for 21 days lowered the degree of tubular damage to the kidney rectus of white rats (Rattus norvegicus) male streptozotocin-induced strains.

10aDiabetic rat10aStichopus hermanii10aTubular injury1 aSetianingsih, Herin1 aWisnumarta, Satria, Erda1 aTjandra, Sareh, Arjono uhttps://phcogj.com/article/1618