02156nas a2200229   4500008004100000245012000041210006900161260001400230300001400244490000700258520141900265653001501684653005301699653001601752653000901768100003001777700001301807700002901820700002301849700001801872856003601890       2021                        eng d00aAnti-Cancer Potential of Nggorang Leaves Extract (Salvia Occidentalis SW.) as a Protein P53 Supressor in T47D Cells0 aAntiCancer Potential of Nggorang Leaves Extract Salvia Occidenta  cJuly 2021  a1036-10450 v133 a<p class="rtejustify">Breast cancer is one of the most common types of cancer in women. The high incidence of breast cancer has led to the development of anticancer drugs that are more selective against cancer cells without damaging normal tissues. One of the alternatives in cancer treatment by looking for natural sources that can be developed, Nggorang leaves (<em>Salvia occidentalis </em>Sw.). This plant is found in Tenda Village, Langke Rembong District, Manggarai Regency, NTT Province, when the leaves are harvested for one year and are used as medicine. As a preventive, this leaf has been used for generations as an anticancer (7 leaves boiled with 200 ml of water to 100 ml and then drunk), for wounded breast cancer (crushed leaves and attached to the wound); stamina enhancer, cough, influenza, hemorrhoids, diarrhea, nosebleeds (Primary data, 2014). This study aims to prove the potential of EDG (Nggorang Leaves Extract) as an antiproliferative against Hela cancer cells and protein P53 suppressor. The method used is the Quasy experiment, because this study uses laboratory tests in sample testing. The results of the cytotoxic test of Nggorang Leaves Extract have the potential to be anti-proliferative against cancer cells T47D IC50 at 201 ppm and Nggorang Leaves Extract (EDG) has the potential to increase p53 gene suppression in T47D cancer cells by 94.13% at a concentration of 50 ppm.</p>
10aAnticancer10aNggorang Leaves Extract (Salvia occidentalis Sw)10aProtein P5310aT47D1 aDewi, Sisilia, Teresia Ro1 aSabir, M1 aPakadang, Sesilia, Rante1 aKamal, Sainal, Edi1 aSinala, Santi  uhttps://phcogj.com/article/1629