02692nas a2200337 4500008004100000245012600041210006900167260001900236300001400255490000700269520153600276653001801812653001701830653000901847100003101856700003301887700002901920700003401949700003001983700003302013700003102046700003102077700002902108700002402137700002702161700003302188700004202221700002902263700002602292856003602318 2021 eng d00aTotal Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz & Pav.) Mez. Bark0 aTotal Phenol Content and Gastric AntiUlcer Activity of Hydroalco cSeptember 2021 a1072-10780 v133 a

Objective: Determine the content of total phenols and evaluate the gastroprotective effect of the extract of Persea caerulea (Ruiz & Pav.) Mez. in mice with induced gastric ulcer. Material and Methods: The bark of Persea caerulea was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female Mus musculus Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups P. caerulea treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. Results: Higher percentages of gastric ulcer inhibition were obtained in the P. caerulea 100 mg/kg (80%) and P. caerulea 200 mg/kg (85.71%) groups. Conclusions: Extract of Persea caerulea (Ruiz & Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.

10aGastric ulcer10aIndomethacin10aMice1 aCalderón-Peña, Abhel, A.1 aAspajo-Villalaz, Cinthya, L.1 aSilva-Correa, Carmen, R.1 aLa Torre, Víctor, E. Villarr1 aGonzález-Blas, María, V1 aPretel-Sevillano, Orlando, E1 aSalazar-Castillo, Marco, L1 aVaella-Alarcón, Maricielo1 aHuaccha-Cáceres, Franco1 aLeón-Soto, Jonatam1 aAlaya-Davirán, Whendy1 aGonzález-Siccha, Anabel, D.1 aSagástegui-Guarniz, William, Antonio1 aGuerrero-Espino, Luz, M.1 aHilario-Vargas, Julio uhttps://phcogj.com/article/1635