02523nas a2200217 4500008004100000245007100041210006900112260001900181300001400200490000700214520192000221653001402141653001802155653002002173100000502193700001802198700001802216700001602234700001902250856003602269 2021 eng d00aAmelioration of Cisplatin-Induced Kidney Injury by Pometia pinnata0 aAmelioration of CisplatinInduced Kidney Injury by Pometia pinnat cSeptember 2021 a1257-12680 v133 a

Introduction: Cisplatin is one of the most effective anticancer drugs. But using cisplatin can cause very serious nephrotoxicity and acute kidney injury (AKI). Pometia pinnata (PE) or commonly referred to as matoa is a typical plant, especially Papua, Indonesia. Pometia pinnata belongs to the Sapindaceae family. This study aimed to determined the nephroprotective activity of the extract ethanol pometia pinnata on rats induced cisplatin. Methods: 30 rats are divided into six groups, each group were contained 5 rats. Group I was a normal group which rats only given CMC (carboxy methyl celluloce). Group II was a negative group which rats injected 7 mg / kgbw of Cisplatin in day 3. Group III was a positive group which rats given vitamin C 1% from day 1 to 7 and in day 3 rats were injected cisplatin. Group IV-VI were extract groups (100 mg / kgbb, 200 mg / kgb, 400 mg / kgbb) which rats orally given extract from day 1 to 7 and in day 3 rats were injected cisplatin. On day 8 rats were injected ketamine 1% which directly took the blood from the heart. Results: The result shows that EEPE on rats biochemical parameters including urea, creatinine, uric acid. Group II showed that there was a significant increase (p <0.05) compared to the normal group that was not given cisplatin and extracts. Whereas in the group given the extract in groups IV, V, and VI there was a reduction in biochemical parameters because the Pometia leaf extract had high antioxidant activity so that it had nephroprotective activity. extract ethanol pometia pinnata can reduced the level of sodium, potassium and chloride of each group after receiving cisplatin. Statistically group II that only given cisplatin has significantly different with group I (p<0,05) and also statically different with group VI (p<0,05).

10aCisplatin10aKidney injury10aPometia pinnata1 a1 aSyahputra, RA1 aLie, Sukirman1 aNugraha, SE1 aSitumorang, PC uhttps://phcogj.com/article/1656