01897nas a2200241 4500008004100000245008800041210006900129260001900198300001400217490000700231520119900238653001801437653000901455653000901464653001201473653001201485100002601497700003401523700002301557700001601580700002301596856003601619 2021 eng d00aIn Vivo Antimammary Tumor Effects of Soybean Extract with Targeted Lunasin (ET-Lun)0 aIn Vivo Antimammary Tumor Effects of Soybean Extract with Target cSeptember 2021 a1269-12760 v133 a

Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo.

10aBreast cancer10aEGFR10aHER210aIn-vivo10aSoybean1 aRusdi, Numlil, Khaira1 aPurwaningsih, Erni, Hernawati1 aHestiantoro, Andon1 aElya, Berna1 aKusmardi, Kusmardi uhttps://phcogj.com/article/1657