01856nas a2200205 4500008004100000245018900041210006900230260001800299300001400317490000700331520113800338653002201476653001701498653002001515653000801535653003101543100002301574700001701597856003601614 2021 eng d00aSyzygium Cumini Leaves Extract from West Sumatra Indonesia Alleviate Oxidative Stress by Decreasing Malondialdehyde Level and Enhancing Catalase Activity in Rat Induced by Lead Acetate0 aSyzygium Cumini Leaves Extract from West Sumatra Indonesia Allev cNovember 2021 a1408-14120 v133 a

Introduction: Lead is one of the most dangerous heavy metals in the environment. Contaminated drinking water, battery manufacturing, lead paints, and industrial pollutants are all sources of lead exposure. Lead exposure can cause oxidative stress and is related to many health problems. To prevent oxidative stress caused by lead, the body needs additional antioxidants from the outside body. Syzygium cumini leaf is abundant in antioxidants, which help to minimize oxidative stress caused by lead. Methods: The rats were divided into three groups: negative control, positive control (lead acetate 40 mg/kg BW, 30 days), and treatment (lead acetate 40 mg/kg BW and Syzygium cumini leaves extract 150 mg/kg BW, 30 days). At the end of the experiment, blood was collected and prepared to measure malondialdehyde and catalase activity. Results: The leaf extract of Syzygium cumini reduced serum malondialdehyde levels while increasing catalase activity. Conclusion: Lead exposure induces oxidative stress, which can be reduced by Syzygium cumini’s leaves.

10aCatalase activity10aLead acetate10aMalondialdehyde10aRat10aSyzygium cumini’s leaves1 aRita, Rauza, Sukma1 aSy, Elmatris uhttps://phcogj.com/article/1676