02014nas a2200181 4500008004100000245011400041210006900155260001800224300001400242490000700256520138700263653006301650100001901713700001501732700002301747700002601770856003601796 2021 eng d00aSyzygium polyanthum (Wight.) Walp Ethanol Extract Decreased Malondialdehyde Level in Type 2 Diabetic Patients0 aSyzygium polyanthum Wight Walp Ethanol Extract Decreased Malondi cDecember 2021 a1557-15610 v133 a

Background: Beside conventional oral antidiabetic, many diabetic patients used plant as an alternative medicine. One of the plants is Syzygium polyanthum Wight. Walp. Previous study showed that ethanolic extract of Syzygium polyanthum (Wight.) Walp leaves (EESP) is safe to be consumed by healthy volunteer. Aim: The present study was conducted to investigate the effect of EESP on malondialdehyde (MDA) level in type 2 diabetes mellitus volunteers. Materials and Methods: EESP was obtained by maceration then formulated in capsules (weight of 350 mg). A total of 12 volunteers were randomly given EESP or Placebo/ Pl (amylum) once daily for 14 days in conjunction with metformin 500 mg twice daily. Hemoglobin (Hb), liver and kidney function and MDA were measured at the beginning and at the end of the study. Results: After 14 days administration of EESP, Hb 12.52± 1.23 (g/dL), SGOT 24.16±13.57 (U/L), SGPT 27.50 ± 20.52 (U/L), ureum 23.12±13.27 (mg/dL), creatinine 0.71 ± 0.23 (mg/dL) while MDA 1041.63 ± 615.66 ng/mL in EESP treated group. The reduction of MDA level in EESP-treated group (24%) were higher than Pl-treated group (16%). Conclusion: S. polyanthum leaf extract is potential as antioxidant in type 2 diabetes mellitus patients.

10aDiabetes mellitus; Extract; Malondialdehyde; S. polyanthum1 aWidyawati, Tri1 aPase, Aron1 aDaulay, Milahayati1 aSumantri, Imam, Bagus uhttps://phcogj.com/article/1702