02258nas a2200217 4500008004100000245009900041210006900140260001800209300001400227490000700241520156900248653001401817653002001831653001001851653001801861100002901879700003101908700003401939700003101973856003602004 2021 eng d00aEffect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice0 aEffect of a Gel Based on Ipomoea batatas Purple Sweet Potato on  cDecember 2021 a1720-17260 v133 a

Background: Ipomoea batatas (L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. Objective: To evaluate the healing activity of a gel based on I. batatas on dermal wound healing in mice. Material and methods: An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of I. batatas "purple sweet potato", which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel I. batatas 0.5%) and Group IV (Gel I. batatas 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. Results: Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. Conclusions: The 1% gel based on the ethanolic extract of the peels of the roots of Ipomoea batatas (L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.

10aHistology10aIpomoea batatas10aSkin.10aWound Healing1 aSilva-Correa, Carmen, R.1 aOrtiz-Noriega, Cristel, M.1 aLa Torre, Víctor, E. Villarr1 aCalderón-Peña, Abhel, A. uhttps://phcogj.com/article/1715