02539nas a2200289 4500008004100000245011400041210006900155260001800224300001400242490000700256520164300263653002601906653002401932653002201956653001901978100003101997700001702028700002902045700003102074700001902105700001802124700001802142700000502160700002902165700001902194856003602213 2021 eng d00aAntidiabetic Activity of Extract and Fractions of Castanopsis costata Leaves on Alloxan-induced Diabetic Mice0 aAntidiabetic Activity of Extract and Fractions of Castanopsis co cDecember 2021 a1589-15930 v133 a

Background: In North Sumatra, Castanopsis costata is commonly used by traditional practitioners for the treatment of diabetes mellitus, however, no studies have been carried out to substantiate this practice. Therefore, this study aims to evaluate the anti-diabetic activity of extract and fractions of C. costata leaves in mice with alloxan-induced diabetes. Methods: Swiss albino mice with alloxan-induced diabetes, were acquired and subjected to the experimental evaluations. Subsequently, the fasting blood glucose levels of the diabetic mice groups treated with glibenclamid, extract and fractions, as well as the untreated group, were evaluated after two weeks of therapy. Results: Based on the results, the ethanolic extract of C. costata considerably reduced the mice’s blood glucose levels in a dose-dependent manner, at dosages of 25, 50, 100, and 200 mg/kgBW (% DBGL: 21.10%, 46.36%, 58.94%, and 60.93%, respectively). In addition, the water fraction of C. costata leaves produced a greater reduction in blood glucose levels (% DBGL: 78.93%), compared to the ethyl acetate and n-hexane fractions (% DBGL: 67.06% and 58.83%), respectively. Meanwhile, treatment with the antidiabetic drug, glibenclamide (5 mg/kgBW) produced a 50.75% reduction in blood glucose levels. Conclusion: Based on the findings, the extract and fractions of C. costata leaves were concluded to exhibit significant anti-diabetic activity. This supported the claim that traditional practitioners in North Sumatra use the plant extract for diabetes treatment.

10aAntidiabetic activity10aCastanopsis costata10aDiabetes mellitus10aNorth Sumatra.1 aAlkandahri, Maulana, Yusuf1 aSujana, Dani1 aHasyim, Dadang, Muhammad1 aShafirany, Mareetha, Zahra1 aSulastri, Lela1 aArfania, Maya1 aFrianto, Dedy1 a1 aKusumawati, Anggun, Hari1 aYuniarsih, Nia uhttps://phcogj.com/article/1716