02473nas a2200277 4500008004100000245009200041210006900133260001400202300001200216490000600228520162200234653001601856653001701872653002001889653002001909653001001929100003201939700002901971700002702000700002702027700002802054700002402082700002502106700002902131856003502160 2016 eng d00aStudy on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed0 aStudy on Inflammation and the Nervous system of Ethanol extract  cJune/2016 a335-3400 v83 a

Introduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of J. curcas seeds. Materials and methods: It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of J. curcas seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. Results: According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of J. curcas; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements outcomes reveal a positive dose response manner. Regard to neurological manifestations, Straub tail was founded in doses of 400 mg/kg. Stereotypies were founded in doses of 400, 600, 800 and 1000 mg/kg throughout the evaluation. Conclusion: J. curcas seeds were showed an inflammatory effect. In addition, effects on the nervous system were founded as stereotypes and Straub tail.

10aCarrageenan10aInflammation10aJatropha curcas10aNervous System.10aSeeds1 aAlexander, Zambrano-Huailla1 aRommel, Zambrano-Huailla1 aSergio, Goicochea-Lugo1 aErnesto, Zavala-Flores1 aJorge, GarcĂ­a-Berrocal1 aAngel, Chau-Saravia1 aCarlos, Pante-Medina1 aAlberto, Salazar-Granara uhttps://phcogj.com/article/174