02351nas a2200325 4500008004100000245015100041210006900192260001500261300001200276490000700288520122600295653002301521653001701544653002001561653001901581653002101600653001401621100002801635700003401663700002901697700003201726700003601758700002701794700002901821700003201850700003601882700003101918700004001949856003601989 2022 eng d00aPasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice0 aPasuchaca Geranium ruizii Hieron A Medicinal Plant of the Gerani cApril 2022 a315-3210 v143 a

Objective: The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of Geranium ruizii on alloxan-induced hyperglycemia in albino mice. Material and Methods: Geranium ruizii was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (Geranium ruizii extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. Conclusion: The hypoglycemic effect of the hydroalcoholic extract of Geranium ruizii, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.

10aAntidiabetic drugs10aAntioxidants10aGeranium ruizii10aHerbal therapy10aMedicinal plants10aPasuchaca1 aHerrera-Calderon, Oscar1 aHañari-Quispe, Renan, Dilton1 aTinco-Jayo, Johnny, Aldo1 aPari-Olarte, Josefa, Bertha1 aChacaltana-Ramos, Luz, Josefina1 aLoyola-Gonzales, Eddie1 aIparraguirre-Meza, Melva1 aPrivat, Mildred, Hilda Cón1 aGaldos-Vadillo, Beatriz, Lilian1 aMendoza-Vilcahuaman, Jenny1 aMuñoz-de-la-Torre, Rossibel, Juana uhttps://phcogj.com/article/1769