02377nas a2200217 4500008004100000245014200041210006900183260001500252300001200267490000700279520166600286653002601952653001301978653001801991653002802009100002802037700001902065700002102084700001802105856003602123 2022 eng d00aMechanism of the Bioactive Sargassum cristaefolium in Inhibiting Inflammatory Mediators in a Nitroglycerin-Induced Migraine Model in Rats0 aMechanism of the Bioactive Sargassum cristaefolium in Inhibiting cApril 2022 a388-3960 v143 a

Background: Migraine headaches are a form of sterile neurogenic inflammation. The sterile inflammatory process of the trigeminal nerve releases the vasoactive neuropeptide CGRP which stimulates the release of inflammatory mediators. In the incidence of migraine there is an increase in TNF-α and IL-10. Sargassum cristaefolium ethanol extract contains flavonoids, alkaloids, triterpenoids, steroids, and tannins, which has analgesic and anti-inflammatory function. Method: Sargassum cristaefolium was extracted using maceration method with 70% ethanol as solvent. Animal models were divided into 5 groups and given NTG induction 5 times with 1 day intervals, treated for 3 weeks. All data were analyzed using IBM SPSS version 26.0. Results: Sargassum cristaefolium ethanol extract - CGRP levels β: -0.26, p: 0.17; Sargassum cristaefolium ethanol extract - CGRP expression β: -0.04, p: 0.85; Sargassum cristaefolium ethanol extract - TNF-α levels β: -0.63, p: 0.01; Sargassum cristaefolium ethanol extract - TNF-α expression β: -0.40, p: 0.04; Sargassum cristaefolium ethanol extract - IL-10 levels β: 0.77, p: 0.00; Sargassum cristaefolium ethanol extract - IL-10 expression β: 0.45, p: 0.01. Conclusions: A significant path between the administration of Sargassum cristaefolium ethanol extract and a decrease in TNF-α and an increase in IL-10. But the effect of giving Sargassum cristaefolium ethanol extract on CGRP levels did not have a significant relationship.

10aInflammatory mediator10aMigraine10aNitroglycerin10aSargassum cristaefolium1 aAdam, Olivia, Mahardani1 aNugraha, Jusak1 aHamdan, Muhammad1 aTurchan, Agus uhttps://phcogj.com/article/1779