02581nas a2200241 4500008004100000245008300041210006900124260001500193300001200208490000700220520179600227653001202023653001502035653001902050653002302069100003902092700003502131700003502166700003802201700003502239700002902274856003602303 2022 eng d00aAnxiolytic and Antidepressant-like Effects of Foeniculum vulgare Essential Oil0 aAnxiolytic and Antidepressantlike Effects of Foeniculum vulgare  cApril 2022 a425-4310 v143 a

Introduction: The aim of this research was to determine the anxiolytic and antidepressant-like effects of the essential oils from Foeniculum vulgare aerial parts and seeds. Methods: The oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and chemical composition was performed by Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). Furthermore, an experimental trial was conducted, where 117 participants were divided into three groups, comprising a waiting list control group and two experimental groups treated with essential oils. The anxiety and depression indexes were evaluated by Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS). Results: chemical analysis showed that trans- Anethole was the main component, both in the essential oil from aerial parts (35.5%) and seeds (79.2%). Anxiety and depression scores showed a decrease in posttest study phase in comparison with pretest in all experimental groups (p<0.05), except for depression scores in the group treated with essential oil from aerial parts (p>0.05). Small changes were found in the case of anxiety for group treated with essential oils from aerial parts (d = 0.41; Δ= 0.40) while moderate (d = 0.86; Δ = 0.85) and small (d = 0.38; Δ = 0.39) changes were found for anxiety and depression respectively, in the group treated with essential oil from seeds. Conclusion: The essential oil from Foeniculum vulgare seeds is more effective to relief anxiety than depression while the essential oil from Foeniculum vulgare aerial parts only exhibit small changes for anxiety.

10aAnxiety10aDepression10aEssential oils10aFoeniculum vulgare1 aAlvarado-García, Paul, Alan Arkin1 aSoto-Vásquez, Marilú, Roxana1 aRosales-Cerquin, Luis, Enrique1 aRodrigo-Villanueva, Elda, Maritza1 aJara-Aguilar, Demetrio, Rafael1 aTuesta-Collantes, Lurdes uhttps://phcogj.com/article/1783