02143nas a2200217 4500008004100000245016100041210006900202260001500271300001200286490000700298520135400305653001801659653003601677653001501713653005501728653003701783100002301820700002001843700002601863856003601889 2022 eng d00aColeus atropurpureus (L) Benth. Leaves as a New Promising Drug for Abscesses Caused by Methicillin-resistant Staphylococcus aureus and Staphylococcus aureus0 aColeus atropurpureus L Benth Leaves as a New Promising Drug for  cApril 2022 a439-4430 v143 a

Background and Objective: Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) can cause an abscess, a skin condition with a build-up of pus due to a fluid or pus-filled tissue covering. This study aimed to determine the antibacterial activity of the ethanolic extract and its fraction from jawer kotok (Indonesian), Coleus atropurpureus (L) Benth.) against abscess-causing bacteria, S. aureus and MRSA. Materials and Methods: Laboratory Experimental Design. C. atropurpureus was collected, macerated using 96% ethanol extract, then fractionated using ethyl acetate and n-hexane. Antibacterial properties of ethanol extract and its fraction using S. aureus ATTC 25923 and MRSA. Statistical analysis used: descriptive statistics. Results: It was found that the MIC values for S. aureus ATTC 25923 and MRSA were in the range of 0.78% - 1.56% w/v and the MBC value for the two test bacteria was 1.56% Conclusions: Ethanol extract and n.hexane fraction from C. atropurpureus were new drugs for abscess treatment. It is necessary to research the formulation and evaluation of the ethanolic extract and the n-hexane fraction from C. atropurpureus against the two bacteria that cause abscesses first.

10aAntibacterial10aColeus atropurpureus (L) Benth.10aMaceration10aMethicillin-resistant Staphylococcus aureus (MRSA)10aStaphylococcus aureus ATTC 259231 aMustarichie, Resmi1 aIskandar, Yoppi1 aSaptarini, Nyi, Mekar uhttps://phcogj.com/article/1785