01842nas a2200229 4500008004100000245017000041210006900211260001400280300001200294490000700306520107700313653002801390653002301418653001001441653002401451653002001475100002001495700001601515700001901531700002601550856003601576 2022 eng d00aSubchronic Toxicity Studies of a Combined Andrographis paniculata (Burm.f.) Nees, Syzygium cumini (L) Skeels, and Caesalpinia sappan L Extract in Sprague-Dawley Rats0 aSubchronic Toxicity Studies of a Combined Andrographis paniculat cJune 2022 a531-5350 v143 a

Introduction: Andrographis paniculata, Syzygium cumini and Caesalpinia sappan (ASC) are plants that are widely used as traditional medicines in treating diabetes. The acute toxicity test results of the combination of these three plants were safe up to 5000 mg/Kg BB. Objectives: To evaluate subchronic toxicity of a combined ASC extract. Methods: Male and female Sprague Dawley rats were acclimatized for 14 days and then fed a normal diet with ASC extract at doses of 150, 575 and 1000 mg/kg BW daily for 135 days. At the end of the study, the rats were sacrificed and then blood, heart, pulmonary, liver, kidneys, spleen and pancreas were collected. Result: The results showed no abnormality in the experimental group compared with the control group. All values of other parameters assessed remained within the normal range. Conclusions: The combination of ASC extract given orally for 135 days to male and female rats did not show any subchronic toxicity.

10aAndrographis paniculata10aCaesalpinia sappan10aRats.10aSubchronic yoxicity10aSyzygium cumini1 aSolawati, Atini1 aElya, Berna1 aSetiawan, Heri1 aPratiwi, Raysa, Yunda uhttps://phcogj.com/article/1799