02191nas a2200289   4500008004100000245014300041210006900184260001600253300001200269490000700281520124300288653001301531653003301544653002401577653001701601653001701618100001901635700002801654700002701682700003801709700002701747700001801774700001801792700002101810700003401831856003601865       2022                        eng d00aAmino Acid and Proximate Analysis of Type-1 Collagen from Sea Cucumber and Tilapia-Skin and its Potential Application as Artificial Tendon0 aAmino Acid and Proximate Analysis of Type1 Collagen from Sea Cuc  cAugust 2022  a358-3610 v143 a<p class="rtejustify">Tendon injury is a medical indication that requires surgical therapy and prolonged recovery. Collagen plays a crucial role in the wound healing process. Collagen maintains homeostasis, interacts with platelets, and enhances cellular components. Most living organisms consist of collagen components as fibrillar proteins. In this study, the potential properties of type-1 collagen from sea cucumber and Tilapia-skin were evaluated depend on proximate analysis, amino acid composition, and moisture-absorption ability. The result showed that Tilapia-skin has a higher protein and fat composition compared to the sea cucumber. In contrast, moisture, ash, and yield composition showed higher for sea cucumber compared to Tilapiaskin. Meanwhile, based on amino acid analysis was revealed that proline, alanine, methionine, isoleucine, leucine, phenylalanine, and lysine were lower on sea cucumber compared to Tilapia-skin. In conclusion, both type-1 collagen material from sea cucumber and Tilapia-skin might be developed as a biomaterial for tendon injury. It is crucial that further studies be carried out to emphasize the potential of biodegradable and bio-replaceable materials using the<em> in vivo </em>model.</p>
10acollagen10aKey words: Artificial tendon10aMarine biodiversity10aSea cucumber10aTilapia-skin1 aSafira, Arifia1 aRani, Cinta, Atsa Mahes1 aPuspitasari, Roro, Ayu1 aAyuningtyas, Anindyta, Kirana Put1 aMahendra, Yayang, Amru1 aPurnomo, Agus1 aFikri, Faisal1 aChhetri, Shekhar1 aPurnama, Muhammad, Thohawi El  uhttps://phcogj.com/article/1842