02533nas a2200277 4500008004100000024000700041245011300048210006900161260001700230300001200247490000700259520170400266653002001970653000901990653002201999653001702021653001902038100001902057700002502076700002602101700002102127700002102148700002502169700002502194856003602219 2022 eng d a1900aAntiurolithiatic Activity of Aqueous Extract of Ziziphus lotus on Ethylene Glycol-Induced Lithiasis in Rats 0 aAntiurolithiatic Activity of Aqueous Extract of Ziziphus lotus o cOctober 2022 a596-6020 v143 a

In Morocco, Ziziphus lotus is commonly used as an urolithiatic agent in the traditional medicine. To confirm this effect, an aqueous extract of Ziziphus lotus (AEZL) has been studied in ethylene glycolinduced urolithiasis model of rats. 30 male rats were randomly divided into five groups of six animals each. Group I served as a vehicle control and received distilled water (0.5 ml/100 g p.o.). All remaining groups received calculi inducing treatment for 28 days, comprised of 0.75% v/v ethylene glycol with 1% w/v ammonium chloride in drinking water ad libitum for 3 days followed by only 0.75% v/v ethylene glycol for 25 days. Group II served as lithiatic control and received distilled water (0.5 ml/100 g p.o.). Group III served as curative treatment group and received AEZL at doses of 150 mg/kg from 14th day to 28th day. Group VI served as preventive treatment group and received AEZL at doses of 150 mg/kg from 1st day to 28th day. Group V served as therapeutic and received a drug “Cystone” at dose of 750 mg/kg from 14th day to 28th day. The extract treatment decreased the levels of oxalate and calcium in urine. Crystalluria analysis showed that untreated rats excreted large CaOx monohydrate and few dihydrate crystals while treated animals excreted mostly small CaOx dihydrate crystals. Significant similarity was observed between preventive and therapeutic anti-urolithiatic effect of AEZL and anti-urolithiatic effect of cystone (P<0.001). These results demonstrated that AEZL have an anti-urolithiatic effect with preventive and therapeutic treatments in this experimental condition.

10aEthylene glycol10aRats10aUrinary parameter10aUrolithiasis10aZiziphus lotus1 aChakit, Miloud1 aBoussekkour, Rezklah1 aHessni, Aboubaker, El1 aBahbiti, Youssef1 aNakache, Redouan1 aMustaphi, Hicham, El1 aMesfioui, Abdelhalim uhttps://phcogj.com/article/1876