02697nas a2200337 4500008004100000024000700041245015400048210006900202260001500271300001200286490000700298520173000305653001602035653000902051653001502060653001302075653001102088653000802099653001802107653001602125100003202141700000502173700002102178700001802199700002302217700001402240700001802254700003002272700002102302856003602323 2023 eng d a2100aAnalysis of The Effect of Leptin, AMPK, Adiponectin, and NPY Markers on Changes in Body Weight of Childhood Epileptic Using Valproic Acid Monotherapy0 aAnalysis of The Effect of Leptin AMPK Adiponectin and NPY Marker cMarch 2023 a150-1530 v153 a

Introduction: Epilepsy is a neurological disorder that occurs due to abnormal neurons in the brain and an imbalance between excitation and inhibition in the central nervous system. The first line of OAE in children is VPA (Valproate Acid). However, long-term use can cause weight gain with a frequency of 10-70%. The underlying mechanism of weight gain in patients remains unclear. Purpose: This study aimed to analyze the relationship between levels of biomarkers AMPK, NPY, Leptin, and Adiponectin on changes in body weight in patients with epileptic seizures using VPA monotherapy. Method: This study is an observational cohort design. Data collection in April-June 2019. Inclusion criteria were children aged 2-10 years who used VPA requirement less than two years, not taking any drugs that affect body weight, not diagnose systemic lupus, nephrotic syndrome, and diabetes mellitus. Bodyweight and all biomarkers measurement on subjects who came to the clinic at the time of study and at least after one month of taking VPA. A total of 17 subjects participated in this study. Result: The results of the statistical multivariate analysis test of VPA dosage on changes in body weight and biomarker levels found that Leptin, AMPK, Adiponectin did not significantly increase in body weight (p>0.05), but NPY significant increase in body weight (p<0.05). Conclusion: NPY is the most potent for appetite enhancing, preferential effect on carbohydrate intake, weight regulation, energy storage, and expenditure. Increase production of NPY, there is an increase in energy intake and then increases fat storage and body weight.

10aAdiponectin10aAMPK10aChildhood.10aEpilepsy10aLeptin10aNPY10aValproic acid10aWeight gain1 aIslamiyah, Wardah, Rahmatul1 a1 aMachin, Abdulloh1 aErnawati, Iin1 aTanti, Yunita, Dwi1 aJaya, Nur1 aMedina, Farah1 aRahmadanita, Fathia, Faza1 aSugianto, Paulus uhttps://phcogj.com/article/1960