01625nas a2200193 4500008004100000024000700041245008200048210006900130260001500199300001200214490000700226520104500233653002201278653001801300653002301318100002601341700002801367856003601395 2023 eng d a2400aMolecular Docking and ADME Studies of Centella Asiatica as Anti Hyperuricemia0 aMolecular Docking and ADME Studies of Centella Asiatica as Anti  cApril 2023 a384-3890 v153 a

Centella asiatica is a traditional natural medicine used in a number of Southeast Asian nations. (also known as Centella asiatica L., Urb., or Gotu Kola). The aim of this study is to determine the antihyperuricemia properties of Centella asiatica extract and the possibility that they will interact with the XDH enzyme. The XDH enzyme is one of three enzymes that can influence the onset of hyperuricemia with the other two are SLC22A12 and ABCG2. In this research, we employ a computational method in collaboration with a number of applications and databases. ADME analysis was carried on for some Centella asiatica constituents to determine their similarities to the drug and bioavailability components. The analysis continued on with molecular docking between the chemical compounds and several enzymes related to hyperuricemia. According to the findings, Centella asiatica contains active constituents that can be used as an alternative therapy for hyperuricemia.

10aCentella asiatica10aHyperuricemia10aMolecular Docking.1 aJamil, Ahmad, Shobrun1 aSaputro, Prayogi, Galie uhttps://phcogj.com/article/2013