02555nas a2200229 4500008004100000024000700041245010800048210006900156260001400225300001200239490000700251520186700258653002702125653002502152653001302177653001702190653001202207100002002219700002202239700002802261856003602289 2023 eng d a1900aFactors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis0 aFactors Affecting the LongTerm Protection Against Hepatitis B Im cJune 2023 a385-3940 v153 a

Introduction: Hepatitis B virus (HBV) infection is a major global health issues and one of the most dangerous viral infections with a high mortality rate. Newborns and infant vaccination against chronic HBV infection are crucial for preventing mother-to-child transmission (MTCT). This study aimed to conduct a meta-analysis to investigate the factors affecting long-term protection against Hepatitis B Immunization in infancy. Material and Methods: Our literature searches are from PubMed, Science Direct, Web of Science, and ProQuest publications between January 2000 and December 2021. The included literature assessed the risk of bias using the Newcastle Ottawa Quality Assessment Scale. We identify Hepatitis B surface antibodies (anti-HBs) ≥ 10 mIU/mL as being protective against HBV infection. The results are combined with a random effect or fixed effect model. Results: Eighteen eligible observational studies with a total of 16,642 participants were included. Analysis of factors affecting long-term protection status by assessing anti-HBs titers showed significant results on several factors, including gestational age for anti-HBs titers (OR 2.5; 95% CI 1.62-3.85; p<0.0001), weight for age to anti-HBs titers (OR 1.36; 95% CI 1.06-1.75; p=0.02), length for age to anti-HBs titers (OR 0.01; 95% CI 0.01-0.02; p<0.00001), and immunization status based on the number of vaccine doses (4 doses vs 3 doses) to anti-HBs titers (p<0.00001). Conclusions: Anti-HBs titers of hepatitis B immunization were significantly affected by gestational age, weight for age, length for age, and vaccine doses. Parents of newborns must be informed about basic immunization and provide adequate nutritional intake to the mother and babies to prevent HBV infection.

10aHepatitis B antibodies10aHepatitis B vaccines10aImmunity10aImmunization10aInfant.1 aPratiwi, Aldila1 aSetyoboedi, Bagus1 aWungu, Citrawati, D. K. uhttps://phcogj.com/article/2045