02354nas a2200301 4500008004100000024000700041245012500048210006900173260001400242300001200256490000700268520135500275653001401630653001601644653002201660653001601682653002501698100002801723700003201751700003301783700002801816700003801844700003601882700002901918700003701947700003201984856003602016 2023 eng d a2700aTanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model0 aTanacetum Parthenium L Sch Bip From Peru Antioxidant Profile and cJune 2023 a435-4370 v153 a

Background: Tanacetum parthenium (L.) Sch Bip known as “santa maría” (Asteraceae family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. Objective: The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of T. parthenium Material and Methods: Leaves and flowers of T. parthenium were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method. Results: Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC50 showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. Conclusions: The ethanolic extract of flowers of T. parthenium showed a high antioxidant activity and antinociceptive effect in mice.

10aAnalgesic10aAntioxidant10aMedicinal Plants.10aPolyphenols10aTanacetum parthenium1 aHerrera-Calderon, Oscar1 aBulege-Gutiérrez, Wilfredo1 aJavier-Silva, Luz, Alexandra1 aMeza, Melva, Iparraguir1 aSanchez-Araujo, Victor, Guillermo1 aMelgar-Merino, Elizabeth, Julia1 aTinco-Jayo, Johnny, Aldo1 aAlmeida-Galindo, José, Santiago1 aPari-Olarte, Josefa, Bertha uhttps://phcogj.com/article/2053