01498nas a2200193 4500008004100000024000700041245008700048210006900135260001400204300001200218490000700230520094900237653002601186653001101212653001101223653001701234100001701251856003601268 2023 eng d a3300aThe Role of CYP3A4 and CYP2C8 Polymorphism on Amiodarone Responses: Review Article0 aRole of CYP3A4 and CYP2C8 Polymorphism on Amiodarone Responses R cJune 2023 a467-4700 v153 a

Introduction: Amiodarone is one of drug with narrow therapeutics index. This medicine was metabolized by CYP3A4 and CYP2C8. The changes in the activity of this enzymes by CYP3A4 and CYP2C8 polymorphism will affect the effect. The study aimed to determine the impact of CYP3A4 and CYP2C8 polymorphism on amiodarone responses. Method: the study is review article with search article in PubMed with keywords: ‘amiodarone’ and ‘polymorphism of CYP3A4’ and ‘polymorphism of CYP2C8’. Results: We collect 46 references to determine of impact polymorphism of CYP3A4 and CYP2C8 on amiodarone responses. Conclusion: Individual with CYP3A4*22 (rs35599367, 15389C>T); CYP2C8*2 (A805T), CYP2C8*3 (G416A, A1196G), and CYP2C8*4 (C792G) and CYP2C8*4 polymorphism have lower activity of CYP3A4 and CYP2C8 enzymes and potentially cause adverse effect.

10aAmiodarone responses.10aCYP2C810aCYP3A410aPolymorphism1 aSutrisna, Em uhttps://phcogj.com/article/2059