02366nas a2200397 4500008004100000024000700041245012100048210006900169260001600238300001200254490000700266520123600273653001201509653001501521653001201536653002201548653002601570653001401596100002101610700002001631700001701651700002001668700002501688700002801713700001701741700001801758700000501776700002301781700002401804700002201828700002501850700002101875700002001896700001601916856003601932 2023 eng d a1800aInteraction of Cynaroside from Orthosiphon Aristatus Plant Extract on TNF Alpha as a Stimulant in Malaria and Asthma0 aInteraction of Cynaroside from Orthosiphon Aristatus Plant Extra cAugust 2023 a581-5860 v153 a

This research aims to investigate the interaction between cynaroside, a natural compound found in Orthosiphon aristatus plant extract, with TNF Alpha as a stimulant in the context of malaria and asthma. The research method involved an in-silico approach using software such as Pymol, PyRx, Protein Plus, and the Lepinski Rule. The results of the study showed that cynaroside has a significant interaction with TNF Alpha, as indicated by high Binding Affinity values of -9.6, -9.3, and -9.2. Analysis using Protein Plus confirmed the interaction between cynaroside and TNF Alpha. Additionally, evaluation using the Lepinski Rule of Five revealed that cynaroside has physicochemical characteristics suitable as a potential drug compound, with a mass of 448, hydrogen bond donors of 7, hydrogen bond acceptors of 11, log p -0.401, and molar reactivity of 105.2. These findings provide a deeper understanding of the potential of cynaroside in regulating the immune response to malaria and asthma through its interaction with TNF Alpha. These results can serve as an important basis for further research in the development of more targeted and effective therapies for both of these diseases

10aAsthma.10aCynaroside10aMalaria10aMolecular docking10aOrthosiphon aristatus10aTNF Alpha1 aZainul, Rahadian1 aVerawati, Rismi1 aAlam, Gemini1 aNisyak, Khoirun1 aSari, Trisna, Kumala1 aGhifari, Muhammad, Arya1 aRuga, Ritbey1 aAzhari, Putri1 a1 aBarroroh, Himmatul1 aMandeli, Riso, Sari1 aPurnamasari, Devi1 aKharisma, Viol, Dhea1 aJakhmola, Vikash1 aRebezov, Maksim1 aAnsori, ANM uhttps://phcogj.com/article/2083