02819nas a2200265 4500008004100000024000700041245010700048210006900155260001600224300001200240490000700252520200200259653001602261653001402277653001202291653002102303100002302324700003602347700003102383700002802414700002202442700002302464700003002487856003602517 2023 eng d a2000aAnti-inflammatory Potential of Glycoside Flavonoids from Pterocarpus erinaceus Poir. (Fabaceae) Leaves0 aAntiinflammatory Potential of Glycoside Flavonoids from Pterocar cAugust 2023 a593-5980 v153 a

Background: Chronic diseases have become one of the leading causes of death worldwide in recent years. Despite tremendous advances in the treatments of diseases, several concerns remain. Those with inflammatory components are alternatively treated or completed in Burkina Faso with medicinal plants. The present study was designed to identify and evaluate the anti-inflammatory potential of glycoside flavonoids from Pterocarpus Erinaceus leaves. Methods: The flavonoids contained in Pterocarpus Erinaceus aerial parts were extracted, identified, and characterized. Sequential soxhlet extraction was subjected to preliminary phytochemical screening, and characterization of isolated flavonoid was done by U.V., I.R., 1H & 13C N.M.R. and MS. Subsequently, isolates were tested in vitro for their antiinflammatory potential as well as their antioxidant capacities. Results: Five compounds were determined as corresponding to 3’,4’,5,7-tetrahydroxy flavone (luteolin); quercetin-3-O- sophoroside; quercetin- 3-0-β-glucose (isoquercitrin); Kaempferol-3-O-sophoroside and 3,3’,4’,5,7-pentahydroxyflavone-3- rhamnoglucoside (rutin). Concentrations of quercetin-3-O- sophoroside and quercetin-3-0-β-glucose that inhibit 50% of pro-inflammatory enzymes’ activities were expressed in μg/mL. They were respectively 18.07 ± 0.78 and 32.27 ± 2.02 for xanthine oxidase, 1.12 ± 0.018 and 11.53 ± 0.52 for lipoxygenase, 26.91 ± 0.34 and 19.54 ± 0.25 for acetylcholinesterase. Prevention of the degradation of deoxyribose test gave respectively 19.32 ± 1.08 μg/mL and 26.21 ± 2.25 μg/mL for quercetin-3-O- sophoroside and quercetin-3-O- β-glucose while the anti-DPPH free radical potential was 3.41 ± 0.82 and 2.90 ± 0.18 μg/ mL. Conclusion: These results may justify the traditional uses of P. erinaceus in treating diseases with an inflammatory component.

10aAntioxidant10aCompounds10aEnzymes10aMedicinal plant.1 aOuédraogo, Noufou1 aBelem-Kabré, Leila, Marie Esth1 aThiombiano, A.M., Emmanuel1 aTraoré, Tata, Kadiatou1 aBelemnaba, Lazare1 aOuédraogo, Moussa1 aGuissou, Innocent, Pierre uhttps://phcogj.com/article/2085