02013nas a2200217 4500008004100000024000700041245011700048210006900165260001700234300001200251490000700263520131000270653002001580653002901600653002301629653002801652653002701680100002901707700002301736856003601759 2023 eng d a1900aTotal Phenolic and Flavonoid Contents, Anti-tyrosinase and Antioxidant Activities of Pachyrhizus erosus Extracts0 aTotal Phenolic and Flavonoid Contents Antityrosinase and Antioxi cOctober 2023 a839-8420 v153 a

Background: The storage roots of Pachyrhizus erosus (PE) have been traditionally used as a skin whitening agent in Indonesia and are also consumed fresh in many Southeast Asian countries, including Thailand. However, research on the biological activities of PE is limited. Objective: This study aimed to measure the total phenolic and flavonoid contents and to test the anti-tyrosinase and antioxidant activities of PE extracts. The Folin-Ciocalteu colorimetric, the Aluminium chloride colorimetric, the DPPH scavenging, and the Dopachrome assays were used for the experiments. Results: The dichloromethane extract had the highest anti-tyrosinase activity (IC50= 2.08 ± 0.40 mg/mL), total flavonoid content (9.93 ± 0.02 mg QE/g extract), and antioxidant activity (IC50= 40 ± 0.02 μg/mL). The largest total phenolic concentration was found in the 80% ethanol extract, albeit (11.97 ± 0.55 mg GAE/g extract). Conclusion: Based on its remarkable activities, the dichloromethane extract is recommended for future development in skinlightening products. The study's findings conclude that PE extracts may be used as an alternate source of antioxidants and anti-tyrosinase agents

10aAnti-tyrosinase10aFree radical scavenging.10aPachyrhizus erosus10atotal flavonoid content10atotal phenolic content1 aLaovachirasuwan, Pornpun1 aPhadungkit, Methin uhttps://phcogj.com/article/2127