02191nas a2200241 4500008004100000245014300041210006900184260001800253300001400271490000700285520144900292653001101741653001801752653001001770653000901780653001401789100002801803700001901831700001801850700002501868700002001893856003601913 2023 eng d00aExtract of Torbangun (Coleus amboinicus Lour) Leaves Inhibits the Expression of PEPCK and G6Pase in Streptozotocin-Induced Diabetic Rats0 aExtract of Torbangun Coleus amboinicus Lour Leaves Inhibits the  cDecember 2023 a1116-11200 v153 a

Objective: This study aimed to analyze the anti-hyperglycemic activity of Torbangun leaf extract (TLE) in hyperglycemic rats by observing its effect on blood glucose levels and PEPCK and G6Pase gene expression. Method: This post-test-controlled group design study used a completely randomized design (CRD). Seven rats were separated as a normal group (N) and other rats were injected with streptozotocin (STZ). Hyperglycemia was characterized by fasting blood glucose (FBG) >126 mg/dl. Hyperglycemic rats were divided into three groups: H-IM (control drug metformin hydrochloride dose 62.5 mg/kg BW), H-IT (TLE dose 620mg/kg BB), and NG (negative control, hyperglycemic rats). Rats were given intervention for 14 days. Result: The results showed a significant difference between initial and final FBG of the HI-IM group (p = 0.002, α = 0.01) and the H-IT group (p = 0.005, α = 0.01) and effect on the key gene expression of gluconeogenesis in the liver. The H-IT group showed a decrease in PEPCK gene expression 0.80 times and decreased G6Pase gene expression by 0.65 times compared to NG group. Conclusion: The findings suggested the administration of TLE in STZ-induced hyperglycemic rats was able to reduce blood sugar levels and was involved in inhibiting the expression of PEPCK and G6Pase expression genes in the liver.

10aG6Pase10ahyperglycemia10aPEPCK10aRats10aTorbangun1 aAndrestian, Meilla, Dwi1 aDamanik, Rizal1 aAnwar, Faisal1 aYuliana, Nancy, Dewi1 aMallongi, Anwar uhttps://phcogj.com/article/2171