02070nas a2200229 4500008004100000245011600041210006900157260001800226300001400244490000700258520135700265653001801622653003001640653001801670653001301688100001801701700002401719700002501743700001601768700002001784856003601804 2023 eng d00aEthanolic Extract of Propolis from Tetragonula laeviceps: Selective Cytotoxicity for MCF-7 Breast Cancer cells0 aEthanolic Extract of Propolis from Tetragonula laeviceps Selecti cDecember 2023 a1177-11800 v153 a

Introduction: Many patients with breast cancer fail to respond to conventional chemotherapeutic agents; these agents are also associated with numerous adverse events and toxicities. These concerns have led to the ongoing search for natural ingredients with antitumor effects. As such, the aim of this study was to explore the anti-cancer properties of an ethanolic extract of propolis (EEP), a natural product derived from the stingless bee, from Tetragonula laeviceps. Methods: Bioactive components of EEP were identified by gas chromatography–mass spectrometry (GC–MS) and antioxidant capacity was tested by 2.2-diphenyl1-picrylhydrazyl (DPPH) analysis. Selective cytotoxic actions of EEP on both MCF-7 and Vero cells were then evaluated using the MTT assay. Polyphenols were identified as the major components of EEP from T. laeviceps. Results: our results indicated that EEP was selectively toxic for human MCF-7 breast cancer cells and had only limited impact on African Green Monkey kidney Vero cells. Conclusion: EEP from T. laeviceps has bioactive components that may selectively inhibit the proliferation of cancer cells. As such, EEP may be useful source material to be used for the development of novel anti-cancer agents.

10aBreast cancer10aMCF-7 Breast Cancer Cells10aProliferation10aPropolis1 aMasadah, Rina1 aEkawardhani, Savira1 aPutra, Ramadani, Eka1 aIkram, Dzul1 aFaruk, Muhammad uhttps://phcogj.com/article/2181