01937nas a2200205   4500008004100000245009200041210006900133260001800202300001200220490000700232520133300239653001501572653001101587653001601598653000901614100001901623700002801642700002501670856003601695       2024                        eng d00aPunicalagin Opposes Gentamicin Nephrotoxicity in Rats: Role of Nrf2 and NF-κB Pathways0 aPunicalagin Opposes Gentamicin Nephrotoxicity in Rats Role of Nr  cFebruary 2024  a126-1300 v163 a<p class="rtejustify"><strong>Background:</strong> Oxidative stress, inflammation, and apoptosis are implicated in gentamicin (GEN)-induced nephrotoxicity. Punicalagin (PNG) possesses antioxidant, anti-inflammatory, and antiapoptotic effects. Objective: The aim of the present research was to investigate the possible defensive effect of PNG against nephrotoxicity caused by GEN in male Sprague-Dawley rats. <strong>Materials and Methods:</strong> GEN (80 mg/kg/day, i.p.) was administered for 8 days. Treatment with PNG (25 mg/kg/day, p.o.) for 10 days, began 2 days before GEN insult. <strong>Results: </strong>PNG significantly decreased serum creatinine, and malondialdehyde, tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, nuclear factor-κB p65 (NF- κB p65), and cleaved caspase-3 activity in the kidneys of GEN-challenged rats. PNG also significantly increased renal catalase, reduced glutathione, and nuclear factor erythroid 2-related factor 2 (Nrf2) in rats received GEN. Additionally, PNG markedly attenuated the histopathological kidney tissue injury caused by GEN. <strong>Conclusion: </strong>PNG guarded against GEN-induced kidney damage in rats through its antioxidant, anti-inflammatory, and antiapoptotic effects, and by modulating the balance between Nrf2 and NF-κB pathways.</p>
10aGentamicin10aKidney10aPunicalagin10aRats1 aFouad, Amr, A.1 aAli, Moataz, Mohamedalh1 aAbdel-Hamid, Mostafa  uhttps://phcogj.com/article/2218