02110nas a2200205 4500008004100000245005500041210005200096260001500148300001200163490000700175520152700182653002801709653002701737653001601764100002601780700001801806700001801824700002601842856003601868 2024 eng d00aAn Ulcerative Cutaneous Plasmacytosis of the Scalp0 aUlcerative Cutaneous Plasmacytosis of the Scalp cApril 2024 a378-3810 v163 a

Introduction: Cutaneous plasmacytosis (CP) is a rare benign disorder characterized by polyclonal proliferation of plasma cells of unknown etiology, with potential for malignant transformation. Clinical manifestations include reddish-brown macules, papules, plaques, or nodules, and, infrequently, ulcerative lesions resembling cutaneous squamous cell carcinoma (SCC) or similar cutaneous neoplasms. Case: Herein we reported a case of ulcerative CP which was initially suspected as SCC in a 77–year–old male. Physical examination revealed an ulcer with well–defined borders, and flat edges, with a granulation tissue base on the scalp which was suggested as SCC. Histopathological features showed infiltration of mature plasma cells in the perivascular area, polyclonal plasma cell population on kappa and lambda chain immunohistochemistry, and hypergammaglobulinemia on protein electrophoresis that supported the diagnosis of CP. Discussion: Cutaneous plasmacytosis requires a comprehensive diagnostic evaluation, which typically includes clinical examination, histopathological analysis, immunohistochemistry, ancillary tests such as protein electrophoresis, and negative results from a diagnostic workup for systemic disease. Conclusion: The complexity of CP manifestations necessitates a rigorous diagnostic approach, enabling the differentiation of this benign condition from malignancies with similar presentations.

10aCutaneous plasmacytosis10aHypergammaglobulinemia10aPlasma cell1 aSutedja, Eva, Krishna1 aYustiana, Eva1 aFaldian, Yogi1 aUsman, Hermin, Aminah uhttps://phcogj.com/article/2259