01975nas a2200253   4500008004100000245011600041210007000157260001300227300001200240490000700252520123000259653003101489653001901520653002001539653001201559100002201571700002401593700000501617700002201622700001701644700001901661700000501680856003601685       2024                        eng d00aThe Role of α-SMA, Type 1 Collagen, and Myofibroblasts in Cicatrizing Conjunctivitis by Alkali Chemical Trauma0 aRole of αSMA Type 1 Collagen and Myofibroblasts in Cicatrizing C  cMay 2024  a591-5960 v163 a<p class="rtejustify"><strong>Introduction: </strong>Chemical trauma to the eye is a serious condition in the field of ophthalmology and a leading factor contributing to global blindness. Cicatrizing conjunctivitis (CC) is a term used to describe conditions marked by inflammation and the formation of scars on the conjunctiva. CC can have various causes, with one of them being chemical injury to the eye. The development of CC involves the participation of several cytokines and cells, such as α-SMA, Type 1 collagen, and Myofibroblasts. Myofibroblasts have the ability to contract through the utilization of diverse cytoskeletal proteins, which are commonly present in smooth muscle cells, including α-SMA. Actin filaments contribute to mechanically supporting cells, defining cell morphology, and facilitating cell mobility. Actin, in conjunction with myosin, participates in the muscle contraction process within muscle cells. Subsequently, type 1 collagen contributes to the healing of conjunctival wounds by providing a tensile force that aids in the closure of such wounds. As a significant constituent of the extracellular matrix, type 1 collagen plays a crucial role in maintaining the integrity of tissues.</p>
10aCicatrizing conjunctivitis10aMyofibroblasts10aType 1 collagen10aα -SMA1 aHadiyantama, Henu1 aAgustini, Lukisiari1 a1 aKomaratih, Evelyn1 aZuhria, Ismi1 aLestari, Pudji1 a  uhttps://phcogj.com/article/2285