02488nas a2200241 4500008004100000245014600041210006900187260001400256300001200270490000700282520169000289653001501979653002701994653001602021653002202037100002502059700002102084700002802105700002202133700002802155700002702183856003602210 2024 eng d00aEfficacy and Safety of Traditional Transdermal Patch (Ya-Pok- Dud-Pid) in Primary Knee Osteoarthritis Patients: A Randomized Controlled Trial0 aEfficacy and Safety of Traditional Transdermal Patch YaPok DudPi cJune 2024 a570-5750 v163 a

Background: Patients with Knee Osteoarthritis (KOA) have a progressive decline in their social and physical abilities, which affects their quality of life. The Thai Traditional Transdermal Patch (Ya-Pok-Dud- Pid; YP) has been widely used for the treatment of KOA. Objective: To determine the clinical efficacy and safety of YP in comparison with diclofenac gel (DG) for the treatment of KOA. Methods: 74 primary KOA Patients were enrolled and randomly assigned to YP groups or DG groups. The outcomes were assessed the Visual Analog Scale (VAS), Time Up and Go (TUG), Active Knee Flexion (AKF) and Passive Knee Flexion, chair sit and reach, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: YP and DG significantly improved VAS, TUG, AKF, PKF, chair sit and reach, and WOMAC (p < 0.05). Remarkably, YP experienced the same immediate pain relief after day 1 treatment as DG. The VAS scores of the YP group exhibited a significant reduction from 60±11.06 to 38.92±17.76, while DG decreased VAS score from 61.24±17.84 to 39.19±20.05 (p <0.001). However, there was no significant difference between the two treatment groups. For adverse event, skin reaction (rash, itchy, and dry skin) was noted in the YP group because of the participant receiving YP for an extended period. Altogether, YP has a similar effect to diclofenac gel on pain severity and physical function in patients with knee osteoarthritis. Conclusion: YP is recommended as a natural therapeutic agent with efficacy and safety treatment for knee osteoarthritis.

10aDiclofenac10aOsteoarthritis of knee10aTraditional10aTransdermal Patch1 aSaereewat, Chutharat1 aSriyakul, Kusuma1 aTungsukruthai, Parunkul1 aNiempoog, Sunyarn1 aTungsukruthai, Sucharat1 aKamalashiran, Chuntida uhttps://phcogj.com/article/2295